
Gastroenterology billing
Screening or diagnostic, decided from the record before every scope claim goes out.
We bill GI the way payers read a colonoscopy: screening or diagnostic from the reason for the visit, PT, KX or 33 where they apply, biopsy and snare codes matched to the lesions, and sedation and anesthesia coded to follow the scope.
- Full-service rate
- 3% to 6% of collections
- Medicare polyp coinsurance
- 15% in 2026, 10% from 2027
- Screening modifiers
- PT and KX; 33 for commercial
- New & smaller practices
- Flexible monthly minimum
What makes GI billing different
The same colonoscopy can be billed three ways: as a screening, as a screening that turned therapeutic when a polyp came out, or as a diagnostic procedure from the start. Each uses different codes, modifiers and patient cost sharing, and the starting point is why the patient was scheduled, not what the scope found.
Add sedation, pathology and the split between office, ASC and hospital, and one scope can produce three or four claims. We bill the professional side inside our full revenue cycle service, at 3% to 6% of collections.

Colonoscopy codes and the modifiers that go with them
Medicare rules from CMS. Most commercial plans take the CPT codes with modifier 33 instead of the G codes.
- G0121Screening, not high risk. Medicare pays once every 10 years (119 full months), or 47 months after a screening sigmoidoscopy.
- G0105Screening at high risk, such as a history of adenomatous polyps or a parent, sibling or child with colorectal cancer. Every 24 months.
- 45378Diagnostic colonoscopy, the base code of the colonoscopy family.
- 45380Colonoscopy with biopsy: one unit however many biopsies.
- 45384, 45385, 45388Removal by hot biopsy forceps or snare, or ablation. Several polyps removed the same way are one unit.
- PTMedicare: a screening turned diagnostic or therapeutic. Goes on the procedure, anesthesia and sedation codes.
- KXMedicare: a screening after a positive stool-based or blood-based screening test. The usual frequency limits do not apply.
- 33Commercial plans: a preventive screening. Added to the colonoscopy, anesthesia and sedation codes.
When a screening finds a polyp: who pays in 2026
A Medicare screening with nothing removed has no deductible or coinsurance. When a polyp is removed or a biopsy taken, you bill the diagnostic code with PT, and under chapter 18 of the Medicare Claims Processing Manual the deductible stays waived and coinsurance is 15 percent through 2026, 10 percent from 2027 through 2029, and zero from 2030. Without PT, the patient owes the deductible and full coinsurance.
Most commercial plans (all but those grandfathered from March 2010) cannot charge cost sharing for polyp removal during a screening, or for the consultation, prep, anesthesia and pathology with it, per the Departments of Labor, HHS and Treasury. The AGA’s coding guide puts 33 on each code. Our patient billing team explains any balance left.
Colonoscopy after a positive stool or blood test
Medicare counts a colonoscopy after a positive stool-based test (such as FIT or Cologuard) as part of the screening, and since January 1, 2025 a positive blood-based test qualifies too, under 42 CFR 410.37(k). Bill the screening code with KX.
Those commercial plans must cover the follow-up colonoscopy after a positive stool-based test without cost sharing. The USPSTF has not recommended blood-based tests, so commercial coverage of those varies. The screening diagnosis (Z12.11 for the colon) goes first, and many payers want specific history codes, such as Z86.0101 for adenomatous and serrated polyps.
Anesthesia, sedation and where the scope is done
Medicare anesthesia for a screening colonoscopy is 00812, with no deductible or coinsurance; once it turns diagnostic it is 00811 with PT. Moderate sedation by the endoscopist is G0500 for Medicare (99152 for commercial), plus 99153 for added time, with 33 on a screening and, for Medicare, PT once it turns diagnostic.
In the office (place of service 11), Medicare pays one rate covering the physician, staff and equipment. In an ASC (24) or hospital outpatient department (22 or 19), the physician’s rate covers only the physician’s share and the facility bills its own fee. For 2026, the fee schedule final rule cut work RVUs for most procedures by a 2.5 percent efficiency adjustment and gave office settings more indirect practice expense than facilities.
Biopsy, polypectomy and same-day scopes
A biopsy and snare of the same polyp is the snare code alone. Under chapter VI of the 2026 NCCI manual, the edit between 45385 and 45380 is bypassed with 59 or XS only for separate lesions. Control of bleeding and fluoroscopy are part of the scope, and an EGD with biopsy (43239) includes the diagnostic EGD and washings.
Medicare pays two codes from one family, such as 45385 and 45380, under the special endoscopy rule in chapter 12 of the claims manual: the higher code in full plus the difference between the other and the base (45378). An EGD and a colonoscopy the same day get the usual multiple-procedure reduction. An E/M on the scope day needs a separately identifiable reason and modifier 25. An interrupted colonoscopy is billed with 53, at about half its value.
Prior authorization and why GI claims deny
Medicare Advantage, Medicaid and commercial plans keep their own authorization lists, so we check when the procedure is scheduled. Since January 1, 2026, the CMS prior authorization rule gives Medicare Advantage, Medicaid and CHIP 7 calendar days for standard requests and 72 hours for urgent ones, with a specific reason for any denial. Drugs, such as IBD biologics, are outside it.
Common GI denials and cost-sharing errors, with the reason codes that often carry them (codes vary by payer):
- A screening inside the frequency limit, or a follow-on scope without KX (CO-119)
- PT or 33 missing, so the patient is charged a deductible or coinsurance (PR-1 or PR-2)
- Biopsy and snare billed together without 59 or XS (CO-236)
- Screening diagnosis not listed first, or a history code too vague (CO-11)
- An E/M on the procedure day without modifier 25 (CO-97)
- No authorization on file where the plan requires one (CO-197)
Each goes through our denial management process, and our eligibility checks confirm screening coverage, frequency and authorization before the procedure.
How we run gastroenterology billing
Verify before the scope
Coverage, screening frequency, risk status and authorization are checked first.
Classify every case
Screening, screening turned therapeutic, follow-on after a positive test, or diagnostic.
Code from the report
Lesions, techniques, units, modifiers, diagnosis order and sedation are matched to the report.
Work what comes back
Denials and cost-sharing errors are corrected or appealed by payer and reason code.
Report monthly
Collections, days in A/R, denials by reason and screenings billed with cost sharing.
Credentialing for gastroenterology
GI groups usually enroll in three places: every gastroenterologist, PA, NP and CRNA who bills; the endoscopy center or ASC, which bills its own facility fee; and the hospitals where you hold privileges. Our provider credentialing service handles Medicare (PECOS), Medicaid and commercial applications at $189 per payer application, less in bulk.
Not sure your screening claims are coded right? Send us a month of colonoscopy claims with the procedure notes and we’ll check them, free.
Gastroenterology billing questions
Something else? Call +1 786-788-7313. A biller answers.
All questionsIt keeps screening protections, but the code changes. For Medicare you bill the biopsy or removal code with PT instead of G0121 or G0105, and the patient pays a reduced coinsurance with no deductible. Most commercial plans treat polyp removal as part of the screening, with no cost sharing, and want modifier 33.
PT is Medicare’s modifier for a colorectal cancer screening that turned diagnostic or therapeutic, placed on the procedure, anesthesia and sedation codes. Modifier 33 tells a commercial plan the service was a preventive screening, so the no-cost-sharing benefit applies. Medicare also uses 33 on sedation for a screening colonoscopy.
No deductible and 15 percent coinsurance on the procedure codes billed with PT. The coinsurance drops to 10 percent for 2027 through 2029 and to zero from January 1, 2030. Supplemental coverage may pay the 15 percent. Without PT, the patient is charged as for a diagnostic colonoscopy.
For Medicare it is a screening: bill G0121 or G0105 with KX, and the usual frequency limit does not apply. Since 2025 a positive blood-based test counts too. Most commercial plans must cover the follow-up colonoscopy after a positive stool test without cost sharing.
Yes, when they were on different lesions: 45385 for the snare and 45380 for the biopsy, with 59 or XS to bypass the NCCI edit. If one polyp was biopsied and then snared, bill only 45385. Medicare pays the pair under its special endoscopy rule, not a 50 percent reduction.
Our full-service rate is 3% to 6% of monthly collections, set by your volume, with no setup or onboarding fees and flexible monthly-minimum plans for new and smaller practices. It covers eligibility checks, prior authorizations, coding, claims, payment posting, denials and A/R follow-up. Your exact rate comes after a free A/R review. Our guide to medical billing costs shows how to compare quotes.
Yes. We don’t list our clients on this site, but ask us and we’ll arrange it: with a current client’s permission, we share their contact details so you can hear how we work from them directly.
From our guides

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The four ways billing companies price their work, the fees that sit outside the rate, and in-house arithmetic built from BLS data, so you can compare quotes on your own numbers.

Send us your last 90 days of GI claims.
We’ll review them free and show you where screening modifiers, polyp codes or sedation are costing you money.
